Ibuprofen-induced papillary necrosis causing bilateral ureteric obstruction.

Area of Science:

• Pediatric Pharmacology
• Nephrology
• Adverse Drug Reactions

Background:

• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are frequently prescribed for pediatric pain and fever management.
• Ibuprofen is generally considered safe and well-tolerated in the pediatric population.
• Serious adverse events associated with ibuprofen in children are uncommon.

Purpose of the Study:

• To report a rare case of acute papillary necrosis and bilateral ureteric obstruction.
• To highlight a potential severe adverse effect of ibuprofen in children.

Main Methods:

• Case report detailing a pediatric patient's presentation and clinical course.
• Review of relevant medical literature on ibuprofen-induced nephrotoxicity.

Main Results:

• The patient developed acute papillary necrosis.
• This condition resulted in bilateral ureteric obstruction.
• The adverse event was attributed to ibuprofen administration.

Conclusions:

• Acute papillary necrosis and bilateral ureteric obstruction are rare but serious complications of ibuprofen use in children.
• Clinicians should be aware of this potential adverse effect when prescribing ibuprofen.
• Further investigation into the mechanisms of ibuprofen-induced nephrotoxicity in susceptible pediatric patients may be warranted.