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In vitro fertilization and the cloacal/bladder exstrophy-epispadias complex: a continuing association
Hadley M Wood1, Denise Babineau, John P Gearhart
1Glickman Urological Institute, Cleveland Clinic, 9500 Euclid Avenue, A100, Cleveland, OH 44195, USA. woodh@ccf.org
Journal of Pediatric Urology
|October 25, 2008
Summary
Children born via in vitro fertilization (IVF) show a higher incidence of the cloacal/bladder exstrophy-epispadias complex (CBEEC). This study suggests a potential association between IVF and CBEEC development.
Area of Science:
- Reproductive Medicine
- Pediatric Urology
- Birth Defects Research
Background:
- The cloacal/bladder exstrophy-epispadias complex (CBEEC) is a rare congenital condition.
- Previous research has explored potential links between assisted reproductive technologies and birth defects.
Purpose of the Study:
- To investigate the incidence of CBEEC in children conceived through in vitro fertilization (IVF).
- To determine if there is a statistically significant association between IVF and CBEEC.
Main Methods:
- Data on CBEEC patients conceived via IVF were collected from 1997-2004.
- US IVF birth data and CBEEC incidence rates were obtained from national and international registries.
- A Pearson-type chi-squared analysis was used to assess the association between IVF and CBEEC.
Main Results:
- An estimated 322,937 IVF births occurred in the US between 1997-2004.
- The observed incidence of IVF in CBEEC patients evaluated was 4.2%-6.7%, significantly higher than the expected 0.60%-1.59%.
- A bootstrapped P value of 0.0182 indicated a statistically significant association (P < 0.05).
Conclusions:
- The incidence of IVF in children with CBEEC is higher than expected under the assumption of no association.
- Findings suggest a potential link between in vitro fertilization and the development of CBEEC.
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