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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
Association of a history of varicella virus infection with multiple sclerosis
Mayela Rodríguez-Violante1, Graciela Ordoñez, Jesus Ramirez Bermudez
1Neurodegenerative Diseases Clinical Research Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Objective:
To analyze the association of a previous history of varicella virus infection with multiple sclerosis (MS) and its subtypes.
Material And Methods:
We performed a case-control study including 126 cases and 157 controls. Subjects were divided into subgroups according to MS subtype and the history of varicella virus infection along with other variables was assessed.
Results:
History of varicella zoster virus (VZV) infection was positive in 42% of controls and 66% of MS cases (p
Conclusions:
An association between varicella infection history and MS was found, particularly in the RR subtype.
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