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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Genetic Material01:20

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.

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Related Experiment Video

Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

HGVbaseG2P: a central genetic association database.

Gudmundur A Thorisson1, Owen Lancaster, Robert C Free

  • 1Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK.

Nucleic Acids Research
|October 25, 2008
PubMed
Summary
This summary is machine-generated.

The Human Genome Variation database of Genotype to Phenotype information (HGVbaseG2P) centralizes genetic association study data. This resource aids researchers in distinguishing true genetic signals from false positives, improving data accessibility.

Related Experiment Videos

Last Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Genomics
  • Human Genetics
  • Bioinformatics

Background:

  • Genetic association studies generate vast amounts of data.
  • Accessing and interpreting this data for genotype-phenotype relationships is challenging.
  • A centralized repository is needed to consolidate findings from diverse studies.

Purpose of the Study:

  • To introduce HGVbaseG2P, a novel database for human genetic association study findings.
  • To provide researchers with accessible genotype-to-phenotype (G2P) data.
  • To facilitate the distinction between true and false positive genetic signals.

Main Methods:

  • Construction of the HGVbaseG2P database.
  • Data aggregation and organization from human genetic association studies.
  • Development of website tools for data searching, browsing, and visualization.

Main Results:

  • HGVbaseG2P has been successfully constructed and populated with data.
  • User-friendly tools enable efficient access to G2P study findings.
  • The database supports the identification of reliable genetic associations.

Conclusions:

  • HGVbaseG2P serves as a crucial resource for the human genetics research community.
  • Improved data accessibility enhances the ability to validate genetic findings.
  • The database promotes more robust genotype-phenotype correlation analysis.