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Meningioma associated with Werner syndrome--case report--
Takao Tsurubuchi1, Tetsuya Yamamoto, Yoshiko Tsukada
1Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Neurologia Medico-Chirurgica
|October 25, 2008
Summary
This case study highlights a rare meningioma in a patient with Werner syndrome. Careful monitoring is crucial for early detection of potential extracranial tumors in such patients.
Area of Science:
- Neurology
- Oncology
- Genetics
Background:
- Werner syndrome is a rare genetic disorder associated with premature aging and an increased risk of various cancers.
- Meningiomas are tumors that arise from the meninges, the membranes that surround the brain and spinal cord.
Observation:
- A 53-year-old man with Werner syndrome developed multiple meningiomas after osteosarcoma surgery.
- Brain magnetic resonance (MR) imaging revealed tumors in the right convexity and falx cerebri.
- A right convexity tumor was surgically removed and histologically diagnosed as transitional meningioma.
Findings:
- Meningiomas associated with Werner syndrome are more common in men and typically appear in the fourth decade of life.
- While often benign, these meningiomas can be complicated by extracranial tumors, including sarcomas and thyroid carcinomas.
- The patient's postoperative course was uneventful, with no signs of recurrence or new tumor development.
Implications:
- Patients with meningioma and Werner syndrome require vigilant follow-up to screen for additional extracranial malignancies.
- Multimodal imaging techniques such as brain MR imaging, echography, and body computed tomography are essential for comprehensive surveillance.
- This case underscores the complex interplay between genetic predisposition (Werner syndrome) and neoplastic development, necessitating a multidisciplinary approach to patient management.
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