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Published on: May 10, 2024
Risk factors for wheezing in the first year of life
Herberto José Chong Neto1, Nelson Augusto Rosário,
1Medicina Interna, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. h.chong@uol.com.br
Insights
Infant wheezing risk factors include male gender, family asthma history, pets, early daycare, frequent colds, dermatitis, and mold exposure. Vaccinations and home bathrooms were protective. These findings aid in predicting and preventing childhood asthma.
Area of Science:
- Pediatrics
- Environmental Health
- Epidemiology
Background:
- Wheezing in infants is a common respiratory symptom.
- Identifying risk factors is crucial for early intervention and asthma prevention.
- Previous studies have explored various factors, but regional data is essential.
Purpose of the Study:
- To investigate the risk factors associated with wheezing in infants in southern Brazil.
- To identify potential predictors for the development of asthma in early childhood.
Main Methods:
- A cross-sectional study was conducted using the International Study of Wheezing in Infants (EISL) questionnaire.
- Interviews were conducted with parents of 3,003 infants aged 12-15 months across 35 health centers.
- Statistical analysis included univariate and Poisson regression to determine prevalence ratios (PR) and 95% confidence intervals (95%CI).
Main Results:
- Identified risk factors for infant wheezing included male gender (PR=1.14), family history of asthma (mother PR=1.18, father PR=1.20, siblings PR=1.23), presence of pets (PR=1.28), early daycare attendance (4-6 months PR=1.39), frequent colds (≥6 episodes PR=1.32), personal history of dermatitis (PR=1.09), and home mold (PR=1.14).
- Protective factors included up-to-date immunization (PR=0.79) and having an indoor bathroom (PR=0.83).
Conclusions:
- The identified risk factors for infant wheezing are also recognized risk factors for childhood and adolescent asthma.
- These findings can inform strategies for predicting asthma diagnosis and implementing preventive measures in infants.
- Understanding these associations is vital for public health initiatives aimed at reducing the burden of respiratory diseases.
Objective:
To assess risk factors for wheezing in infants in southern Brazil.
Methods:
Cross-sectional study using a standardized and validated questionnaire (Estudio Internacional de Sibilancias en Lactantes, EISL, or International Study of Wheezing in Infants). Parents of infants aged 12-15 months who attended 35 of 107 health centers between August 2005 and December 2006 for regular immunization were interviewed. The association between wheezing and factors studied was made using a prevalence ratio (PR) and confidence interval of 95% (95%CI) to perform a univariate analysis. Factors associated with wheezing in the bivariate analysis were studied using Poisson regression.
Results:
Three thousand and three parents of infants filled out the questionnaire. The risk factors were male gender (PR = 1.14; 95%CI 1.05-1.24), history of asthma in the family [mother (PR = 1.18; 95%CI 1.04-1.33); father (PR = 1.20; 95%CI 1.05-1.39); siblings (PR = 1.23; 95%CI 1.08-1.42)], other pets in the home during pregnancy (PR = 1.28; 95%CI 1.07-1.53), age when child started daycare [0-3 months (PR = 1.15; 95%CI 0.98-1.34); 4-6 months (PR = 1.39; 95%CI 1.24-1.55); 7-12 months (PR = 1.20; 95%CI 1.07-1.35)], six or more episodes of cold (PR = 1.32; 95%CI 1.21-1.44), personal history of dermatitis (PR = 1.09; 95%CI 1.003-1.19), and mold in the home (PR = 1.14; 95%CI 1.04-1.24). Up-to-date immunization (PR = 0.79; 95%CI 0.63-0.98) and bathroom in the home (PR = 0.83; 95%CI 0.68-1.01) were protective factors.
Conclusions:
Independent risk factors for wheezing in the first year of life are also known risks for asthma in children and adolescents. These data are useful to predict the diagnosis of asthma and to promote its prevention (when applicable).
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Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
