Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematopoietic growth factor receptors.

M F Brizzi1, G C Avanzi, L Pegoraro

  • 1Dipartimento di Scienze Biomediche e Oncologia Umana, Universitá di Torino, Italy.

International Journal of Cell Cloning
|July 1, 1991
PubMed
Summary

Hematopoietic growth factor receptors (HRS) and receptor tyrosine kinases (RTK) are two main families. HRS receptors lack a tyrosine kinase domain, while RTKs, like CSF-1-R, have one and can become oncogenic.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of the COVID-19 pandemic on the activity of the Radiological Emergency Department: the experience of the Maggiore della Carità Hospital in Novara.

Emergency radiology·2021
Same author

Association between red cell distribution width and response to methotrexate in rheumatoid arthritis.

Reumatismo·2020
Same author

Retraction Note to: MIR221/MIR222-driven post-transcriptional regulation of P27KIP1 and P57KIP2 is crucial for high-glucose- and AGE-mediated vascular cell damage.

Diabetologia·2018
Same author

Habitat preference and flowering-time variation contribute to reproductive isolation between diploid and autotetraploid Anacamptis pyramidalis.

Journal of evolutionary biology·2016
Same author

Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications.

International journal of obesity (2005)·2015
Same author

Growth arrest specific gene 6 protein concentration in cerebrospinal fluid correlates with relapse severity in multiple sclerosis.

Mediators of inflammation·2013

Area of Science:

  • Molecular biology
  • Cell signaling
  • Oncology

Background:

  • Hematopoietic growth factor receptors (HRS) and receptor tyrosine kinases (RTK) are two distinct families involved in cell signaling.
  • HRS members share common binding domains but lack cytoplasmic tyrosine kinase domains.
  • RTK subclass III, including CSF-1-R and c-kit, possesses an insert in the kinase domain for substrate binding.

Purpose of the Study:

  • To review the structural characteristics and signaling mechanisms of hematopoietic growth factor receptors (HRS) and receptor tyrosine kinases (RTK).
  • To highlight the commonalities and differences between HRS and RTK families.
  • To discuss the implications of RTK alterations in oncogenesis.

Main Methods:

  • Comparative analysis of molecular cloning data for HRS and RTK.
  • Review of existing literature on receptor structure and function.
  • Discussion of signal transduction pathways and oncogenic potential.

Main Results:

  • HRS receptors utilize alpha and beta chains for high-affinity binding, with potential common subunits.
  • Ligand-induced receptor oligomerization activates RTK kinase domains.
  • RTK subclass III members are derived from proto-oncogenes and can lead to constitutive signaling when altered.

Conclusions:

  • Insights into one HRS member's structure and signaling can generalize to others due to shared features.
  • RTK alterations can result in constitutive activation of growth signals, contributing to cancer development.
  • Understanding these receptor families is crucial for deciphering cell growth regulation and disease mechanisms.

Related Experiment Videos