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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: Jun 28, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

[Eczematous dermatitis: contact or/and atopy...].

A Blondeel1

  • 1Service de Dermatologie, C.H.U. Saint-Pierre, Bruxelles. arlette_blondeel@stpierre-bru.be

Revue Medicale De Bruxelles
|October 28, 2008
PubMed
Summary

Diagnosing eczema relies on patient history and clinical exams. Various tests like IgE, RAST, and patch tests aid understanding, but are guided by individual patient factors.

Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Context:

  • Eczema diagnosis and cause identification primarily depend on patient history and clinical evaluation.
  • Thorough patient history should encompass personal and familial atopy indicators and skin contact history.
  • Understanding eczema requires a comprehensive approach integrating clinical findings with diagnostic investigations.

Purpose:

  • To outline the diagnostic process for eczema, emphasizing the role of patient history and clinical examination.
  • To detail various investigations that can aid in understanding the complex etiology of eczema.
  • To highlight that diagnostic tests are not routine but are selected based on individual patient presentation.

Summary:

  • Eczema diagnosis is primarily based on patient history and clinical examination, including atopy signs and skin contacts.

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Related Experiment Videos

Last Updated: Jun 28, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

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  • Investigations such as total IgE, RAST, prick tests, patch tests (PT), semi-open tests (SOT), and repeated open application tests (ROAT) can provide further insights.
  • The selection and application of these diagnostic tests are guided by the patient's specific history and clinical findings, rather than a standardized protocol.

    • Impact:

    • Improved diagnostic accuracy for eczema and its underlying causes.
    • Personalized approach to eczema investigation, optimizing resource utilization.
    • Enhanced understanding of atopic dermatitis and contact dermatitis mechanisms.