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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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[Practical approach to hypereosinophilia]
1Département de Médecine Interne, Hôpital Erasme, Bruxelles. froufoss@ulb.ac.be
Revue Medicale De Bruxelles
|October 28, 2008
Summary
Hypereosinophilia, an elevated eosinophil count, often signals underlying conditions. Hypereosinophilic syndrome involves organ damage, necessitating targeted treatments like imatinib or corticosteroids.
Area of Science:
- Hematology
- Immunology
- Oncology
Context:
- Hypereosinophilia is a frequent clinical observation.
- It is typically linked to various conditions including parasitic infections, allergies, drug reactions, and malignancies.
- When no cause is found and organ damage occurs, it's termed hypereosinophilic syndrome.
Purpose:
- To outline the diagnostic and therapeutic strategies for hypereosinophilia and hypereosinophilic syndrome.
- To highlight the risk of organ damage when eosinophil counts exceed 1500/µL.
- To discuss current and emerging treatment options.
Summary:
- Elevated eosinophil counts (hypereosinophilia) require investigation for underlying causes.
- Hypereosinophilic syndrome is diagnosed with significant eosinophilia and multi-organ involvement.
- Treatment varies from imatinib for specific mutations to corticosteroids, with options like mepolizumab for resistant cases.
Impact:
- Understanding the cause of hypereosinophilia is crucial for effective management.
- Targeting eosinophil reduction is key in preventing organ damage.
- Newer therapies like imatinib and mepolizumab offer targeted approaches for hypereosinophilic syndrome.
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