Related Experiment Video
Updated: Jun 28, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Neutrophilic dermatoses in children
David R Berk1, Susan J Bayliss
1Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA. DBerk@im.wustl.edu
Pediatric Dermatology
|October 28, 2008
Summary
Neutrophilic dermatoses are rare skin disorders in children, marked by skin and tissue inflammation. This review covers classic and pediatric-associated forms, aiding diagnosis and understanding of these conditions.
Area of Science:
- Dermatology
- Pediatrics
- Immunology
Background:
- Neutrophilic dermatoses are rare inflammatory skin conditions characterized by neutrophil infiltration.
- These disorders can affect skin and extracutaneous tissues, often associated with systemic conditions.
- Pediatric cases present unique challenges and diagnostic considerations.
Purpose of the Study:
- To provide an updated review of neutrophilic dermatoses.
- To highlight distinctive features of these disorders in children.
- To discuss pediatric-specific and genodermatosis-associated neutrophilic dermatoses.
Main Methods:
- Literature review of classical and pediatric-associated neutrophilic dermatoses.
- Focus on clinical presentations and associated conditions.
- Inclusion of syndromes like Majeed, SAPHO, PAPA, PFAPA, and others.
Main Results:
- Neutrophilic dermatoses exhibit diverse clinical appearances and associations.
- Distinctive pediatric features are identified for classical forms.
- Pediatric-associated and genodermatosis-linked conditions are detailed.
Conclusions:
- Accurate diagnosis of neutrophilic dermatoses in children requires awareness of specific features.
- Understanding associated conditions like IBD, malignancies, and medications is crucial.
- Review aids clinicians in managing rare pediatric neutrophilic dermatoses and related syndromes.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...