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[Survivin in cancerology : molecular aspects and therapeutic applications]

Mathilde Romagnoli1, Céline Séveno, Régis Bataille

  • 1Inserm, Université de Nantes, UMR 892, Département de recherche en cancérologie 9 quai Moncousu, 44093 Nantes, France. mathilde.romagnoli@univ-nantes.fr

Medecine Sciences : M/S
|October 28, 2008
PubMed

Insights

Survivin, discovered a decade ago, is crucial for cell division and preventing cell death. Aberrant expression in cancers highlights its role as a potential therapeutic target and prognostic marker.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Survivin is a protein with a dual role in mitosis and apoptosis resistance.
  • It plays a physiological role in development but is absent in differentiated adult tissues.
  • Aberrant survivin expression is observed in most human cancers due to activated signaling pathways.

Purpose of the Study:

  • To explore the complex network and signaling pathways involving survivin.
  • To investigate survivin's pro-oncogenic properties.
  • To evaluate survivin as a prognostic marker and anti-tumoral therapy target.

Main Methods:

  • Analysis of survivin's molecular interactions and subcellular localizations.
  • Review of basic and translational studies on survivin's function in cancer.
  • Investigation of signaling pathways intersecting with survivin.

Main Results:

  • Survivin's complex network intersects multiple cell biology pathways.
  • Its pro-oncogenic properties are well-documented.
  • Survivin is implicated in both mitosis regulation and apoptosis resistance.

Conclusions:

  • Survivin's aberrant expression in cancer makes it a significant area of research.
  • Survivin shows promise as a prognostic marker for cancer.
  • Targeting survivin represents a promising strategy for anti-tumoral therapies.

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