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Related Concept Videos

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Structured non-coding RNAs and the RNP Renaissance.

J Robert Hogg1, Kathleen Collins

  • 1Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. jh2721@columbia.edu

Current Opinion in Chemical Biology
|October 28, 2008
PubMed
Summary
This summary is machine-generated.

Non-protein-coding RNAs (ncRNAs) are diverse molecules with increasing functional discoveries. Their roles in protein-rich environments, particularly within ribonucleoprotein complexes, are driving a renaissance in RNA biology.

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An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes
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An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes

Published on: August 18, 2018

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes
09:45

An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes

Published on: August 18, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Non-protein-coding RNAs (ncRNAs) exhibit diverse synthesis, processing, assembly, and functional mechanisms.
  • Recent years have seen a dramatic increase in the identification of transcripts with suspected RNA-based biological roles.
  • Understanding ncRNA function is rapidly advancing, revealing emerging principles of their operation.

Purpose of the Study:

  • To present a framework for understanding ncRNA functions.
  • To differentiate ncRNA evolution in protein-rich environments from the ancestral RNA World.
  • To highlight the significance of ribonucleoprotein (RNP) complexes in ncRNA functional evolution.

Main Methods:

  • Literature review and synthesis of current research on ncRNA.
  • Comparative analysis of ncRNA functions in different cellular contexts (ancestral vs. modern).
  • Focus on the structural and functional interplay between ncRNAs and proteins within RNP complexes.

Main Results:

  • ncRNAs have evolved complex functions within the protein-rich cellular milieu.
  • The ancestral RNA World provides a contrasting backdrop to modern ncRNA roles.
  • ncRNA folding and function within RNP complexes are key drivers of functional innovation.

Conclusions:

  • A framework for understanding ncRNA function in contemporary cells is emerging.
  • The cellular environment profoundly shapes ncRNA functional diversification.
  • The study of ncRNAs within RNP complexes signifies a "RNP Renaissance" in molecular biology.