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Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Jun 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Post-adoption depression among adoptive mothers.

Yehuda Senecky1, Hanoch Agassi, Dov Inbar

  • 1Child Development and Rehabilitation Institute, Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel. Senekimi@zahav.net.il

Journal of Affective Disorders
|October 28, 2008
PubMed
Summary

Adoptive mothers showed a lower rate of depression after adoption compared to before. New-onset depression was not observed, suggesting adoption may alleviate existing depressive symptoms.

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Last Updated: Jun 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

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Published on: September 22, 2023

Area of Science:

  • Psychiatry
  • Maternal Mental Health
  • Adoption Studies

Background:

  • Transition to motherhood can be challenging, with potential for depressive symptomatology.
  • Understanding mental health in adoptive mothers is crucial for targeted support.

Purpose of the Study:

  • To assess depressive symptoms in adoptive mothers during the transition to motherhood.
  • To identify factors influencing these symptoms.

Main Methods:

  • A cohort survey of 39 adoptive mothers of reproductive age.
  • Utilized Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory (BDI), and Brief Symptom Inventory (BSI) before and 6 weeks post-adoption.
  • Compared findings to biological mothers and within the study group pre- and post-adoption.

Main Results:

  • 15.4% of adoptive mothers experienced depressive symptoms post-adoption, similar to general population rates.
  • This rate was lower than the pre-adoption rate (25.6%).
  • All mothers with post-adoption depression also had pre-adoption depressive features; no new-onset depression was observed.

Conclusions:

  • Child adoption does not appear to cause new-onset reactive depression in mothers.
  • Adoption may correlate with a reduction in depressive features.
  • Potential decrease in depression may stem from resolving pre-existing adjustment difficulties.