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Cysts of the neuraxis of endodermal origin
1Department of Pathology, Victoria Hospital, London, Ontario, Canada.
Journal of Neurology, Neurosurgery, and Psychiatry
|July 1, 1991
Summary
Colloid and enterogenous cysts share similar epithelial features and immunohistochemical profiles, suggesting a common origin from primitive foregut endoderm. This finding supports a unified hypothesis for these neuroaxis lesions.
Area of Science:
- Neuroscience
- Developmental Biology
- Pathology
Background:
- Colloid cysts and enterogenous cysts are rare lesions found along the neuroaxis.
- Their distinct origins have been debated, impacting diagnostic and treatment strategies.
Purpose of the Study:
- To investigate the hypothesis that colloid cysts of the third ventricle and spinal enterogenous cysts originate from primitive endodermal tissue.
- To compare the histological and immunohistochemical characteristics of these cyst types.
Main Methods:
- Comparative histological analysis of five colloid cysts and two spinal enterogenous cysts.
- Immunohistochemical staining for cytokeratin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), S-100, vimentin, and glial fibrillary acidic protein (GFAP).
Main Results:
- All lesions exhibited cuboidal/columnar epithelium with goblet cells and cilia.
- Positive immunohistochemistry for cytokeratin, EMA, and CEA in both cyst types.
- Focal S-100 positivity in some colloid and enterogenous cysts; vimentin and GFAP were negative.
Conclusions:
- The shared histological and immunohistochemical features strongly suggest a common origin for colloid and enterogenous cysts from primitive foregut endoderm.
- The presence of identical lesions along the neuroaxis supports this unified developmental hypothesis.