Related Experiment Video
Updated: Jun 28, 2026
10:49
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Inactivated rotavirus vaccines: a priority for accelerated vaccine development
Baoming Jiang1, Jon R Gentsch, Roger I Glass
1Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. bxj4@cdc.gov
Vaccine
|October 28, 2008
Summary
Live oral rotavirus vaccines are effective but have limitations. An inactivated rotavirus vaccine (IRV) offers an alternative approach to ensure global protection against severe diarrhea in children.
Area of Science:
- Vaccinology
- Pediatric Infectious Diseases
- Public Health
Background:
- Live oral rotavirus vaccines are safe and effective in developed nations but raise concerns regarding rare adverse events and broad serotype efficacy.
- Suboptimal immunogenicity and efficacy in African and Asian children necessitate alternative vaccine strategies.
Purpose of the Study:
- To review the rationale for developing an inactivated rotavirus vaccine (IRV) as an alternative to live oral vaccines.
- To evaluate the potential of IRV for global rotavirus prevention, particularly in resource-limited settings.
Main Methods:
- Review of existing studies on rotavirus vaccine efficacy and safety.
- Analysis of animal model data demonstrating the immunogenicity and protective effects of parenteral IRV immunization.
- Assessment of serum antibody responses following IRV administration.
Main Results:
- Parenteral immunization with IRV has shown robust serum antibody responses and protection against rotavirus infection in animal models.
- Serum antibody is a demonstrated protective factor in both animals and children.
Conclusions:
- An inactivated rotavirus vaccine (IRV) presents a viable alternative to live oral vaccines, especially for populations where oral vaccines may be less effective.
- Continued research into alternative rotavirus vaccine approaches is crucial to guarantee global immunization coverage and protect all children from severe rotavirus-induced diarrhea.
Related Concept Videos
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
01:23Vaccine Production
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
01:21Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...