Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Animal model experimentation using the expansile hydrogel intraocular lens.

S B Siepser1, M Wieland

  • 1Surgical Eye Care, Ltd., Paoli, Pennsylvania 19301.

Journal of Cataract and Refractive Surgery
|July 1, 1991
PubMed
Summary

This two-year animal study found that expansile hydrogel intraocular lenses are well tolerated in rabbit eyes. Minimal reactions were observed, confirming the biocompatibility of these advanced intraocular lens implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invited review: Evaluation of teat disinfectant efficacy studies from 2014 to 2026. A systematic review.

Journal of dairy science·2026
Same author

Effects of feeding colostrum volume at 6%, 8%, 10%, or 12% of birth body weight on efficiency of immunoglobulin G absorption, gastric emptying, and postfeeding behavior in Holstein calves.

Journal of dairy science·2025
Same author

An observational study investigating the association of teat condition with clinical mastitis risk.

Journal of dairy science·2025
Same author

Invited review: Contribution of milk harvesting research to optimal interaction between biology and milking technology.

Journal of dairy science·2025
Same author

Monitoring of milking routines for dairy cows using a computer vision system: A diagnostic accuracy study.

Journal of dairy science·2025
Same author

Risk factors for stall unoccupancy in Holstein dairy cows milked 3 times per day in a rotary milking parlor: A case control study.

Journal of dairy science·2025

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Materials Science

Background:

  • Intraocular lenses (IOLs) are crucial for vision restoration after cataract surgery.
  • Hydrogel IOLs offer potential advantages in optical quality and accommodative function.
  • Assessing the long-term biocompatibility of novel IOL materials is essential for clinical safety.

Purpose of the Study:

  • To evaluate the biocompatibility of a novel expansile hydrogel intraocular lens (IOL) over a two-year period in an animal model.
  • To assess the tissue response and material integrity of the hydrogel IOL in vivo.

Main Methods:

  • A two-year animal study involving Dutch-belted rabbits.
  • Phacoemulsification followed by implantation of expansile hydrogel IOLs in four rabbit eyes.

Related Experiment Videos

  • Clinical examinations (slitlamp), gross pathology, histology, and electron diffraction energy dispersive X-ray microanalysis.

    • Main Results:

    • Minimal anterior chamber reaction and lens synechiae observed during slitlamp examinations.
    • Gross pathology and histology revealed hyperplastic residual cortex but indicated good lens tolerance.
    • X-ray microanalysis detected aluminum, silicon, magnesium, and calcium deposition without matrix penetration.

    Conclusions:

    • The expansile hydrogel intraocular lens demonstrated good biocompatibility and tolerance in a two-year rabbit study.
    • The observed tissue reactions were minimal, suggesting the material is suitable for intraocular implantation.
    • Further research may explore the long-term performance and optical stability of these hydrogel IOLs.