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Related Concept Videos

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Published on: June 14, 2016

Surface Mucin-1 does not play a role in dendritic cell migration.

Silvie Cloosen1, Jean-Hubert Caberg, Mariska B Huls

  • 1Department of Internal Medicine, Division of Haematology, University Hospital Maastricht, Maastricht, The Netherlands. S.Cloosen@immuno.unimaas.nl

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|October 28, 2008
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Summary

Mucin-1 (MUC1) on dendritic cells (DCs) does not affect their migration. This study found MUC1 expression did not influence chemokine-induced migration in mature DCs.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mucin-1 (MUC1) is a glycoprotein upregulated on mature dendritic cells (DCs).
  • Surface MUC1 is proposed to play a role in cell migration.
  • Mature DCs are known for their high migratory capacity.

Purpose of the Study:

  • To investigate the role of MUC1 in dendritic cell (DC) migration.
  • To determine if MUC1 expression influences the migratory capacity of mature DCs.

Main Methods:

  • Dendritic cells (DCs) were cultured using two maturation cocktails (TP1,6-DC and RI-DC).
  • MUC1 expression was inhibited using an anti-MUC1 antibody during maturation of TP1,6-DC.
  • Migratory behavior was assessed using Transwell chemotaxis assays and organotypic cultures.

Main Results:

  • Both maturation cocktails induced similar DC surface phenotypes, including CCR7 expression.
  • Only TP1,6-DC exhibited migratory capacity towards a CCL19 gradient.
  • Inhibition of MUC1 expression on TP1,6-DC did not alter their chemokine-induced migratory behavior.

Conclusions:

  • Surface MUC1 on dendritic cells does not influence their intrinsic cell motility.
  • MUC1 is not involved in cell-cell or cell-matrix dependent migration of DCs.