Radioprotection of nonhuman biota
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Updated: Jun 28, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
1Washington State Department of Ecology, Spokane, WA 99205, USA. ddel461@ecy.wa.gov
Abstract:
Radioprotection has historically focused on humans with the assumption that human protection confers protection of nonhuman biota. However, there is a need to scientifically and independently demonstrate protection of nonhuman biota. Approaches to address impacts of radiation on nonhuman biota include applying an ecological risk assessment paradigm, setting dose limits, defining reference organisms, and assessing a geographic region. Recommendations include harmonization of a radioprotection framework for both humans and nonhuman biota, a consistent methodology to evaluate radionuclide and nonradionuclide contaminants, a graded assessment approach, development of dosimetric models for reference organisms, compilation of a radiological effects database, and periodic expert review of methodology.
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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
