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Related Experiment Video

Updated: Jun 28, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

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Published on: January 30, 2020

Inter-hospital variability in post-cardiac arrest mortality.

Brendan G Carr1, Jeremy M Kahn, Raina M Merchant

  • 1The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine (UPENN SOM), USA. Brendan.Carr@uphs.upenn.edu

Resuscitation
|October 28, 2008
PubMed
Summary

Hospital care quality varies for cardiac arrest survivors. Higher volume intensive care units (ICUs) show lower patient mortality, suggesting a volume-outcome relationship in post-cardiac arrest care.

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Area of Science:

  • Intensive Care Medicine
  • Cardiology
  • Health Services Research

Background:

  • Post-cardiac arrest care variability impacts patient outcomes.
  • Understanding hospital-level variations in mortality is crucial for improving care.

Purpose of the Study:

  • To examine hospital-level variation in mortality for patients admitted to U.S. intensive care units (ICUs) with cardiac arrest.
  • To investigate the relationship between hospital volume and post-cardiac arrest patient outcomes.

Main Methods:

  • Utilized the Acute Physiology and Chronic Health Evaluation (APACHE) IV dataset (2002-2005).
  • Identified patients with a primary ICU admission diagnosis of cardiac arrest.
  • Analyzed hospital-level mortality rates, adjusting for patient age and illness severity.

Main Results:

  • 4674 patients from 39 hospitals were analyzed.
  • Overall in-hospital mortality was 56.8%.
  • Hospital mortality rates varied significantly (41%-81% unadjusted, 46%-68% adjusted).
  • Higher patient volume centers demonstrated significantly lower mortality rates.

Conclusions:

  • Significant hospital-level variation exists in severity-adjusted mortality for cardiac arrest patients.
  • A volume-outcome relationship was identified: higher volume ICUs are associated with lower mortality.
  • Further research is needed to identify specific hospital and patient care factors influencing survival.