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Related Experiment Videos

Permanent teeth in hypophosphatasia: light and electron microscopic study.

N G el-Labban1, K W Lee, D Rule

  • 1Institute of Dental Surgery, Eastman Dental Hospital, London, England.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|August 1, 1991
PubMed
Summary

Hypophosphatasia (HPP) causes dental changes, including cementum loss and dentin resorption in permanent and primary teeth. Bacteria in plaque and resorption areas may contribute to tooth loss in HPP patients.

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Area of Science:

  • Dental Science
  • Biomineralization
  • Microbiology

Background:

  • Hypophosphatasia (HPP) is a rare genetic disorder affecting bone and tooth mineralization.
  • Dental anomalies are a hallmark of HPP, impacting both primary and permanent dentition.

Observation:

  • Microscopic examination of permanent and primary incisors from an HPP patient revealed significant dental changes.
  • These changes included cementum loss and extensive dentin resorption areas.
  • Transmission and scanning electron microscopy (EM) identified afibrillar cementum attached to dentin.

Findings:

  • Permanent teeth exhibited similar pathological changes to primary teeth in HPP.
  • A prominent feature was the presence of thick bacterial plaque on all examined teeth.

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  • Bacteria were abundant within dentin resorption bays, suggesting a role in tissue destruction.

    • Implications:

    • Bacterial involvement is implicated in the pathogenesis of dental tissue destruction in hypophosphatasia.
    • Understanding these mechanisms may lead to improved management strategies for HPP-related dental complications.
    • Further research into the bacterial-host interactions in HPP is warranted.