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Published on: July 29, 2014
Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain
Natsuko Nozaki-Taguchi1, Mariko Shutoh, Naohito Shimoyama
1Department of Anesthesiology and Palliative Medicine, Chiba University Graduate School of Medicine, Chuo, Chiba, Japan. nnoztag@faculty.chiba-u.jp
Abstract:
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatitis pain. However, these observations will need to be further confirmed in a randomized-controlled trial.
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