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Thyroid cancer: is the incidence rise abating?
Geneviève Sassolas1, Zakia Hafdi-Nejjari, Laurent Remontet
1Hospices Civils de Lyon, Registre Rhône Alpin des Cancers Thyroïdiens, Fédération d'Endocrinologie et Centre de Médecine Nucléaire Groupement Hospitalier Est, Bron, France.
European Journal of Endocrinology
|October 28, 2008
Summary
Thyroid cancer incidence in France appears to be stabilizing after an initial rise, with papillary microcarcinomas being common and often incidentally discovered. Rural areas show lower thyroid cancer rates than urban zones.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Thyroid cancer incidence has been increasing globally.
- Understanding recent trends and geographical variations is crucial for public health strategies.
Purpose of the Study:
- To determine recent trends in thyroid cancer incidence rates in France.
- To analyze the histopathological characteristics and geographical distribution of thyroid cancer.
Main Methods:
- Analysis of 5367 histologically proven thyroid cancer cases from the Rhône-Alpes thyroid cancer registry (1998-2006).
- Utilized a mixed Poisson model to analyze geographical variations in incidence.
- Age standardization to the world population was performed.
Main Results:
- Average incidence rates were 3.9/100,000 (men) and 12.3/100,000 (women), higher than previously reported.
- Incidence stabilized from 2001-2006 after an initial increase.
- Papillary microcarcinomas (38% of tumors) were frequently small (<5 mm) and incidentally found.
- Lower incidence rates were observed in rural compared to urban zones for both men and women.
Conclusions:
- The rise in thyroid cancer incidence may be abating, potentially due to diagnostic standardization.
- Further long-term studies are needed to confirm these findings.
- Geographical disparities in thyroid cancer incidence warrant further investigation.
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