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Imaging Studies II: Ultrasonography

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Related Experiment Video

Updated: Jun 28, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Simultaneous OCT/SLO/ICG imaging.

Richard B Rosen¹, Mark Hathaway, John Rogers

¹Advanced Retinal Imaging Center, New York Eye and Ear Infirmary, New York, New York 10003, USA. rrosen@nyee.edu

Investigative Ophthalmology & Visual Science

|October 28, 2008

Summary

This summary is machine-generated.

Combined optical coherence tomography (OCT) and indocyanine green (ICG) angiography offers enhanced diagnosis of macular diseases. This integrated imaging approach reveals novel relationships between retinal morphology and function for improved patient care.

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Published on: November 4, 2014

Area of Science:

Ophthalmology
Medical Imaging
Retinal Diseases

Background:

Accurate diagnosis of macular diseases requires detailed visualization of retinal and choroidal structures.
Traditional imaging modalities may not fully capture the complex interplay between morphology and function in various pathologies.

Purpose of the Study:

To evaluate the diagnostic utility of simultaneous coronal optical coherence tomography (OCT) and indocyanine green (ICG) angiography.
To explore how combined OCT and ICG angiography aids in diagnosing diverse macular diseases.

Main Methods:

Utilized a novel OCT/confocal imaging system for simultaneous en face (coronal) OCT and ICG angiography.
Employed fast transverse scanning (T-scanning) for OCT B-scan and C-scan image generation.
Presented OCT, confocal SLO, and ICG fluorescence images simultaneously, with an overlaid mixing channel for direct comparison.

Main Results:

Successfully imaged 30 eyes with various macular conditions, including neovascular membranes, RPE detachments, polypoidal choroidal vasculopathy, and diabetic maculopathy.
Identified novel correlations between morphology and function through superimposed OCT and ICG angiography data.
Demonstrated the ability to visualize late fluorescence accumulation and correlate it with deep retinal structures.

Conclusions:

Simultaneous en face OCT and ICG angiography enable precise correlation of functional fluorescence with anatomical structures at the retina-choroid interface.
Multiplanar OCT scanning provides cross-sectional views of abnormal fluorescence regions.
The synergistic combination of OCT and ICG angiography offers a more comprehensive understanding of macular disease pathology.