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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Updated: Jun 28, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

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Published on: October 8, 2017

Implementation of GenePattern within the Stanford Microarray Database.

Jeremy Hubble1, Janos Demeter, Heng Jin

  • 1Department of Genetics, Stanford University School of Medicine, CA 94305, USA.

Nucleic Acids Research
|October 28, 2008
PubMed
Summary
This summary is machine-generated.

The Stanford Microarray Database (SMD) now integrates GenePattern software, enhancing microarray data analysis capabilities. This open-source extension allows researchers worldwide to access new tools and share analysis pipelines.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The Stanford Microarray Database (SMD) is a widely used platform for storing, annotating, and analyzing microarray data.
  • Existing SMD tools lacked a streamlined method for designing, executing, and sharing analysis pipelines, hindering publication and collaboration.

Purpose of the Study:

  • To integrate the GenePattern software package into the SMD codebase.
  • To enhance SMD's data analysis capabilities and provide a user-friendly interface for creating and sharing analysis pipelines.

Main Methods:

  • Incorporation of the GenePattern software package directly into the existing SMD infrastructure.
  • Development of a plug-in architecture within SMD to facilitate the integration and sharing of additional analysis tools.

Main Results:

  • SMD now offers access to a broader suite of microarray data analysis tools through GenePattern.
  • The integrated system simplifies the design, execution, and documentation of analysis pipelines for researchers.
  • The enhanced SMD is freely available under an Open Source license, enabling wider adoption and local installations.

Conclusions:

  • The integration of GenePattern significantly expands SMD's analytical power and usability for the research community.
  • This open-source extension promotes collaborative research and reproducible microarray data analysis globally.