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The relationship of hyperuricemia and blood pressure in the Thai army population

S Ouppatham1, S Bancha, P Choovichian

  • 1Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.

Journal of Postgraduate Medicine
|October 28, 2008
PubMed

Insights

This study found a positive correlation between serum uric acid levels and blood pressure in a large population. Higher uric acid may be linked to elevated systolic and diastolic blood pressure, suggesting a potential role in hypertension.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Metabolic Disorders

Background:

  • Hypertension and renal disease are linked to gout.
  • The role of serum uric acid as an independent factor in hypertension is debated.

Purpose of the Study:

  • To investigate the association between systolic blood pressure (SBP) and diastolic blood pressure (DBP) and serum uric acid levels.
  • To explore the relationship between serum uric acid and blood pressure in a general population.

Main Methods:

  • Observational study design.
  • Inclusion of 5,564 subjects from the Armed Forces Research Institute of Medical Sciences.
  • Statistical analyses including ANOVA, Chi-square, correlation coefficients, and multiple regression.

Main Results:

  • A significant positive correlation was observed between serum uric acid and SBP (r=0.186, P < 0.001).
  • A significant positive correlation was also found between serum uric acid and DBP (r=0.157, P < 0.001).
  • Higher serum uric acid levels were associated with increased SBP and DBP.

Conclusions:

  • Serum uric acid levels correlate with blood pressure in the general population.
  • Further research is needed to determine hyperuricemia treatment in hypertensive patients.
Abstract

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