Structural basis for exon recognition by a group II intron
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Updated: Jun 28, 2026

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Published on: June 30, 2022
Navtej Toor1, Kanagalaghatta Rajashankar, Kevin S Keating
1Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.
Abstract:
Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.
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