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Updated: Jun 28, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
CADASIL presenting as status migrainosus and persisting aura without infarction
Simona Sacco1, Maurizia Rasura, Marina Cao
1Department of Neurology, The Regional Headache Referral Center, University of L'Aquila, L'Aquila, Italy.
The Journal of Headache and Pain
|October 28, 2008
Summary
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) can present with unusual migraine types. A novel presentation of persistent migraine aura and status migrainosus in CADASIL resolved with lorazepam and mannitol treatment.
Area of Science:
- Neurology
- Neuroscience
- Genetics
Background:
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic small vessel disease.
- Migraine disorders are frequently observed in CADASIL patients, affecting 20-40%.
Observation:
- A novel migrainous manifestation in a CADASIL patient is described.
- This included persistent aura without infarction and status migrainosus.
Findings:
- The patient experienced prolonged migraine aura and status migrainosus.
- Intravenous treatment with lorazepam and mannitol led to symptom resolution.
Implications:
- This case expands the spectrum of neurological presentations in CADASIL.
- It highlights potential therapeutic options for severe migrainous symptoms in this condition.
- Further research into the pathophysiology of migraine in CADASIL is warranted.
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