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Updated: Jun 28, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
Published on: March 18, 2019
SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation
Mark S McMahon1, Yasuyoshi Ueki
1Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA. msmcmahon@att.net
Abstract:
The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.
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