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Updated: Jun 28, 2026
16:24
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
Gene expression profiling of breast cancer
1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 1650 Orleans Street, Baltimore, Maryland 21231, USA.
Advances in Surgery
|October 29, 2008
Summary
Gene expression profiling helps understand breast cancer's genomic complexity. Validated assays like Oncotype Dx and Mammaprint predict outcomes and guide treatment, with more such tests expected.
Area of Science:
- Genomics
- Oncology
- Molecular Diagnostics
Background:
- Breast cancer exhibits significant heterogeneity, necessitating advanced diagnostic tools.
- Gene expression profiling offers insights into the genomic underpinnings of breast cancer.
- Several gene expression profiles have been developed to predict patient outcomes.
Purpose of the Study:
- To review the current landscape of gene expression profiling in breast cancer.
- To highlight the clinical utility and validation status of key assays.
- To discuss the future role of genomic analyses in personalized breast cancer care.
Main Methods:
- Review of scientific literature and clinical trial data.
- Analysis of commercially available gene expression assays.
- Discussion of host factor identification for prognosis and therapy response.
Main Results:
- Gene expression profiles generally show concordance in predicting poor outcomes.
- Oncotype Dx and Mammaprint are well-validated, commercially available assays.
- Ongoing trials are refining the clinical application of these genomic tests.
Conclusions:
- Gene expression profiling is crucial for understanding breast cancer heterogeneity.
- Validated assays are increasingly important for guiding patient treatment.
- Future advancements will likely expand the use of genomic analyses in oncology.
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