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Related Experiment Video

Updated: Jun 28, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Systemic sclerosis/scleroderma: a treatable multisystem disease.

Monique Hinchcliff1, John Varga

  • 1Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA. m-hinchcliff@northwestern.edu

American Family Physician
|October 29, 2008
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis, a connective tissue disease, causes skin hardening and organ damage. Early diagnosis and multidisciplinary care manage complications, improving patient outcomes.

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Related Experiment Videos

Last Updated: Jun 28, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Published on: October 14, 2021

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Systemic sclerosis (Scleroderma) is a chronic autoimmune disease of unknown cause.
  • It leads to microvascular damage and excessive collagen deposition in skin and organs.
  • Raynaud phenomenon and skin hardening are key features.

Purpose of the Study:

  • To summarize the diagnosis, classification, and management of systemic sclerosis.
  • To highlight the importance of early detection and multidisciplinary care for complications.

Main Methods:

  • Clinical evaluation and laboratory testing.
  • Pulmonary function tests, Doppler echocardiography, and CT scans for visceral involvement.
  • Classification into distinct clinical subsets based on organ involvement and autoantibodies.

Main Results:

  • Prognosis is linked to the extent of internal organ involvement.
  • Two distinct clinical subsets exist with varying manifestations and survival rates.
  • Complications are treatable, and organ-specific interventions have improved.

Conclusions:

  • While no disease-modifying therapy is proven, complications of systemic sclerosis are manageable.
  • Integrated, multidisciplinary care is crucial for effective management and limiting end-organ dysfunction.
  • Targeted therapies exist for specific complications like pulmonary arterial hypertension and renal crisis.