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Updated: Jun 28, 2026
06:59
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
Neurologic complications after renal transplant
Nilgul Yardimci1, Turan Colak, Sinasi Sevmis
1Department of Neurology, Baskent University Faculty of Medicine, Ankara, Turkey. ntuncel@yahoo.com
Summary
Neurologic complications are common after renal transplants, often caused by immunosuppressive drugs. Sirolimus is identified as a potential new cause of these neurocomplications.
Area of Science:
- Nephrology
- Neurology
- Transplant Surgery
Background:
- Neurologic complications represent a significant cause of morbidity and mortality in transplant recipients.
- Renal transplantation is a common procedure, making the understanding of its associated risks crucial.
Purpose of the Study:
- To evaluate the nature and incidence of neurologic complications in patients undergoing renal transplantation.
- To identify potential causative agents, including immunosuppressive medications, for these complications.
Main Methods:
- A retrospective review of 132 adult patients who underwent renal transplantation between January 2005 and December 2007.
- Data collected included comorbid conditions, presenting neurologic symptoms, and immunosuppressive drug regimens.
Main Results:
- Twenty neurologic complications were observed in 18 patients, with headaches being the most frequent symptom.
- Immunosuppressive agents were implicated in 16 of the 20 complications, with 50.2% occurring within the first three months post-transplant.
- Cyclosporine, tacrolimus, and sirolimus were the immunosuppressants monitored.
Conclusions:
- Neurologic complications are a notable concern following renal transplantation.
- Sirolimus is suggested as a potential cause of neurocomplications, in addition to cyclosporine and tacrolimus.
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