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A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

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The coagulant response in sepsis.

¹Department of Medicine (F4-219), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. m.m.levi@amc.uva.nl

Clinics in Chest Medicine

|October 29, 2008

Summary

Sepsis can cause blood clotting issues, leading to organ damage. Early diagnosis of sepsis-associated disseminated intravascular coagulation is possible with lab tests and algorithms, and treatments targeting clotting are under investigation.

Area of Science:

Critical care medicine
Hematology
Pathophysiology

Background:

Sepsis frequently involves systemic intravascular coagulation activation.
This activation can lead to fibrin deposition and multiple organ dysfunction.
Complex interactions occur between inflammatory and coagulation pathways.

Purpose of the Study:

To explore the link between sepsis and coagulation.
To highlight diagnostic approaches for sepsis-associated disseminated intravascular coagulation.
To discuss potential therapeutic strategies.

Main Methods:

Review of existing literature on sepsis and coagulation.
Analysis of diagnostic criteria for sepsis-associated disseminated intravascular coagulation.

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

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Last Updated: Jun 28, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

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Published on: February 20, 2021

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Examination of current clinical studies on coagulation inhibition.

Main Results:

Sepsis is strongly associated with intravascular coagulation activation.
Diagnostic algorithms using routine lab tests aid in identifying sepsis-associated disseminated intravascular coagulation.
Coagulation inhibition strategies are theoretically sound and in clinical evaluation.

Conclusions:

Sepsis-induced coagulation activation is a significant contributor to organ dysfunction.
Accessible diagnostic tools exist for sepsis-associated disseminated intravascular coagulation.
Targeting coagulation activation presents a promising therapeutic avenue.