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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
Yakubovich's oscillatority of circadian oscillations models
Denis V Efimov1, Alexander L Fradkov
1Control of Complex Systems Laboratory, Institute of Problem of Mechanical Engineering, Bolshoi Avenue, 61, V.O., St-Petersburg 199178, Russia. efde@mail.ru
Abstract:
The testing procedure of Yakubovich's oscillatority property is presented. The procedure is applied for two models of circadian oscillations [J.C. Leloup, A. Goldbeter, A model for circadian rhythms in Drosophila incorporating the formation of a complex between the PER and TIM proteins, J. Biol. Rhythms, 13 (1998) 70-87; J.C. Leloup, D. Gonze, A. Goldbeter, Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. J. Biol. Rhythms, 14 (1999) 433-448]. Analytical conditions of these models oscillatority are established and bounds on oscillation amplitude are calculated.
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