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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

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Updated: Jun 28, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Who's in charge here? Regulating cell cycle regulators.

Lisa M Bowers1, Elaine B Shapland, Kathleen R Ryan

  • 1Department of Plant & Microbial Biology, 251 Koshland Hall, University of California, Berkeley, Berkeley, CA 94720, USA. lbowers@nature.berkeley.edu

Current Opinion in Microbiology
|October 29, 2008
PubMed
Summary
This summary is machine-generated.

Caulobacter crescentus cell division relies on complex gene regulation networks. These networks control the CtrA protein, essential for DNA replication and cell cycle progression, ensuring proper cell division.

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Last Updated: Jun 28, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Published on: June 6, 2017

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Area of Science:

  • Microbiology
  • Molecular Biology
  • Cell Biology

Background:

  • The cell division cycle of Caulobacter crescentus is governed by intricate transcriptional and signal transduction networks.
  • The activity of CtrA, a critical regulator of DNA replication and cell cycle-regulated genes, oscillates during the cell cycle.

Purpose of the Study:

  • To elucidate the key features of the regulatory networks controlling the Caulobacter crescentus cell division cycle.
  • To understand the transcriptional and post-transcriptional regulation of CtrA and its role in cell cycle progression.

Main Methods:

  • Analysis of transcriptional and signal transduction pathways.
  • Investigation of CtrA protein regulation, including post-transcriptional modifications and proteolysis.
  • Study of protein localization within the cell.

Main Results:

  • Identified key features of transcriptional and signal transduction networks governing the cell cycle.
  • CTR A transcription is regulated by a cascade of transcriptional regulators.
  • CTR A protein is post-transcriptionally regulated by signaling proteins and proteolysis.
  • Pathway proteins localize to opposite cell poles to ensure differential cell fates.

Conclusions:

  • Complex regulatory networks precisely control Caulobacter crescentus cell division.
  • CTR A acts as a central regulator, with its activity modulated by transcriptional and post-transcriptional mechanisms.
  • Spatial organization of regulatory proteins is crucial for generating distinct daughter cell phenotypes.