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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Angioma serpiginosum with sole involvement
Dilek Bayramgurler1, Deniz Filinte, Rebiay Kiran
1Dept of Dermatology, Kocaeli Universitesi Dermatoloji AD Umuttepe, 41080 Kocaeli, Turkey. efe1998@yahoo.com
European Journal of Dermatology : EJD
|October 29, 2008
Summary
Angioma serpiginosum typically affects young girls, but this case presented uniquely on the sole. Immunohistochemistry revealed no hormonal influence, challenging previous theories on estrogen
Area of Science:
- Dermatology
- Vascular Malformations
- Genetics
Background:
- Angioma serpiginosum (AS) is a rare vascular malformation.
- Typically presents as punctate lesions on lower extremities of young females.
- Often follows a serpiginous pattern, rarely Blaschko's lines.
Observation:
- A 16-year-old female presented with AS.
- Lesions followed Blaschko's lines on the entire left lower extremity, including the sole.
- This sole involvement is unprecedented in reported cases.
Findings:
- Immunohistochemical analysis showed no estrogen or progesterone receptors in the affected vessels.
- This finding contradicts the hypothesis of hormonal influence in AS development.
- Suggests a non-hormonal etiology for this specific AS presentation.
Implications:
- Challenges the proposed role of estrogens in Angioma Serpiginosum.
- Highlights the importance of considering rare presentations and Blaschko's lines in AS diagnosis.
- Opens avenues for research into alternativepathogenic mechanisms of vascular malformations.
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