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Related Experiment Video

Updated: Jun 28, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Sex hormone binding globulin and aging.

J D Caldwell¹, G F Jirikowski

¹Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA. jcaldwell@lecom.edu

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme

|October 29, 2008

Summary

Sex hormone binding globulin (SHBG) may actively influence the aging process, impacting conditions like cardiovascular disease and Alzheimer's. Re-evaluating SHBG's role offers new insights into aging and steroid action.

Area of Science:

Endocrinology
Gerontology
Molecular Biology

Background:

Emerging research suggests steroid binding globulin action is more complex than previously understood.
This necessitates a re-examination of steroid levels and the function of binding globulins in aging individuals.

Purpose of the Study:

To review the potential active role of sex hormone binding globulin (SHBG) in the human aging process.
To explore associations between SHBG blood levels and various age-related conditions.

Main Methods:

Literature review focusing on recent research concerning SHBG.
Analysis of data linking SHBG levels to sexual activity, specific cancers, obesity, and chronic diseases.

Main Results:

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SHBG levels change in aging humans and correlate with conditions including prostate issues, breast cancer, obesity, and cardiovascular disease.

Potential relationships between SHBG, HDL-cholesterol, Alzheimer's disease, and osteoporosis are discussed.

Conclusions:

SHBG may act via its own plasma membrane receptors, influencing other cellular pathways.
SHBG is proposed as a critical marker for mating and a key regulator of physiological aging.