Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does the Living My Life Program stay true to the stroke survivors' lens on recovering?

Australian occupational therapy journal·2025

Same author

Effect of nanoparticle stabilization and physicochemical properties on exposure outcome: acute toxicity of silver nanoparticle preparations in zebrafish (Danio rerio).

Environmental science & technology·2013

Same author

Loss of plakophilin 2 disrupts heart development in zebrafish.

The International journal of developmental biology·2012

Same author

Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus.

Evolution & development·2009

Same author

Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos.

The International journal of developmental biology·2009

Same author

Plakoglobin has both structural and signalling roles in zebrafish development.

Developmental biology·2008

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Generation of Mice Derived from Induced Pluripotent Stem Cells

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

Mouse induced pluripotent stem cells.

Eamon Geoghegan¹, Lucy Byrnes

¹Department of Biochemistry, National University of Ireland (NUI), Galway, Ireland.

The International Journal of Developmental Biology

|October 29, 2008

Summary

Induced pluripotent stem (iPS) cells are created by reprogramming somatic cells with specific genes. These iPS cells offer a promising source for patient-specific regenerative medicine, with newer methods reducing tumor risk.

Area of Science:

Stem cell biology
Regenerative medicine
Epigenetics and reprogramming

Background:

Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells.
This reprogramming is achieved through the introduction of specific genes.
iPS cells hold significant potential for patient-specific regenerative therapies.

Purpose of the Study:

To summarize the breakthrough in generating induced pluripotent stem (iPS) cells.
To highlight the potential of iPS cells in regenerative medicine.
To discuss advancements in iPS cell generation, including methods reducing tumor risk.

Main Methods:

Retroviral transduction of four genes (Oct3/4, Sox2, c-Myc, Klf4) to reprogram somatic cells.
Generation of iPS cells with three factors (excluding c-Myc) in recent studies.

More Related Videos

Generation of Induced Pluripotent Stem Cells by Reprogramming Mouse Embryonic Fibroblasts with a Four Transcription Factor, Doxycycline Inducible Lentiviral Transduction System

Generation of Induced Pluripotent Stem Cells by Reprogramming Mouse Embryonic Fibroblasts with a Four Transcription Factor, Doxycycline Inducible Lentiviral Transduction System

Published on: November 13, 2009

Cell Surface Marker Mediated Purification of iPS Cell Intermediates from a Reprogrammable Mouse Model

Cell Surface Marker Mediated Purification of iPS Cell Intermediates from a Reprogrammable Mouse Model

Published on: September 6, 2014

Related Experiment Videos

Last Updated: Jun 28, 2026

Generation of Mice Derived from Induced Pluripotent Stem Cells

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

Generation of Induced Pluripotent Stem Cells by Reprogramming Mouse Embryonic Fibroblasts with a Four Transcription Factor, Doxycycline Inducible Lentiviral Transduction System

Generation of Induced Pluripotent Stem Cells by Reprogramming Mouse Embryonic Fibroblasts with a Four Transcription Factor, Doxycycline Inducible Lentiviral Transduction System

Published on: November 13, 2009

Cell Surface Marker Mediated Purification of iPS Cell Intermediates from a Reprogrammable Mouse Model

Cell Surface Marker Mediated Purification of iPS Cell Intermediates from a Reprogrammable Mouse Model

Published on: September 6, 2014

Assessment of iPS cell pluripotency and contribution to chimeric mice.

Main Results:

Reprogrammed cells (iPS cells) exhibit properties similar to embryonic stem (ES) cells.
Murine iPS cells have demonstrated contribution to germ-line competent chimeric mice.
A three-factor reprogramming method (without c-Myc) yields iPS cells that reduce tumor development risk in chimeric mice.

Conclusions:

Induced pluripotent stem cell technology is a major advancement in stem cell research.
iPS cells are a promising source for patient-specific regenerative medicine.
Further research is refining iPS cell generation for safer therapeutic applications.