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Updated: Jun 28, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Efficient fat suppression by slice-selection gradient reversal in twice-refocused diffusion encoding.

Zoltan Nagy¹, Nikolaus Weiskopf

¹Wellcome Trust Centre for Neuroimaging at University College London, Institute of Neurology, University College London, London, UK. z.nagy@fil.ion.ucl.ac.uk

Magnetic Resonance in Medicine

|October 29, 2008

Summary

This summary is machine-generated.

This study introduces a novel fat suppression technique using slice-selection gradient reversal (SSGR) in diffusion imaging. This method effectively eliminates fat signals without impacting water signals, improving image quality.

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Area of Science:

Magnetic Resonance Imaging
Medical Physics
Biomedical Engineering

Background:

Diffusion imaging commonly uses echo-planar imaging (EPI), which is susceptible to chemical-shift artifacts.
Current fat suppression methods in EPI, like spectral-selective pulses, increase acquisition time and specific absorption rate (SAR).

Purpose of the Study:

To implement and evaluate a fat suppression technique using slice-selection gradient reversal (SSGR) within a twice-refocused spin-echo diffusion sequence.
To assess the efficacy of SSGR in eliminating fat signal without compromising water signal or slice profile.

Main Methods:

Combined slice-selection gradient reversal (SSGR) with a twice-refocused spin-echo sequence for diffusion encoding.
Tested the combined method in phantom and in vivo experiments.

Main Results:

Slice-selection gradient reversal (SSGR) effectively suppressed unwanted fat signals entirely.
Water signal intensity and the slice profile remained unaffected by the SSGR method.

Conclusions:

SSGR is an efficient fat suppression technique for diffusion imaging sequences with two slice-selective refocusing pulses.
This method offers an alternative to conventional fat suppression, potentially reducing acquisition time and SAR.