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Steady state free precession magnetization transfer imaging.

Oliver Bieri1, Tallas C Mamisch, Siegfried Trattnig

  • 1Department of Medical Radiology, University of Basel, Basel, Switzerland. oliver.bieri@unibas.ch

Magnetic Resonance in Medicine
|October 29, 2008
PubMed
Summary
This summary is machine-generated.

Magnetization transfer imaging (MTI) using steady-state free precession (SSFP) is now extended to nonbalanced protocols. This advancement enables MTI of challenging tissues and at ultra-high magnetic fields.

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Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Physics

Background:

  • Magnetization transfer imaging (MTI) traditionally uses balanced steady-state free precession (SSFP) acquisitions.
  • Balanced SSFP methods face limitations with tissues exhibiting high susceptibility variations and at ultra-high magnetic fields due to off-resonance effects.
  • Existing MTI techniques may not be optimal for all anatomical regions or field strengths.

Purpose of the Study:

  • To extend SSFP-based MTI to nonbalanced protocols.
  • To enable MTI of challenging targets like the musculoskeletal system.
  • To improve SSFP-based MTI performance at ultra-high magnetic fields.

Main Methods:

  • Development and application of nonbalanced SSFP protocols for MTI.
  • Analysis of MTI data using magnetization transfer ratio (MTR) histograms in human brain.
  • Acquisition of high-resolution volumetric MTR data at various magnetic field strengths (1.5T to 7.0T).

Main Results:

  • High correlations were found between different SSFP MTI protocols, validating the extension to nonbalanced sequences.
  • Nonbalanced SSFP-based MTI successfully imaged targets with high susceptibility variation.
  • Fast acquisition of high-resolution volumetric MTR data was achieved in human brain and cartilage across a range of magnetic fields.

Conclusions:

  • Nonbalanced SSFP protocols represent a significant conceptual extension for magnetization transfer imaging.
  • This extended MTI approach broadens its applicability to diverse tissues and ultra-high field MRI.
  • The method allows for efficient, high-resolution MTR mapping in various biological tissues.