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Related Experiment Video

Updated: Jun 28, 2026

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Noninvasive mapping of human trigeminal brainstem pathways.

Jaymin Upadhyay1, Jamie Knudsen, Julie Anderson

  • 1PAIN Group, Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA. jayminu@mclean.harvard.edu

Magnetic Resonance in Medicine
|October 29, 2008
PubMed
Summary

Diffusion tensor imaging mapped human trigeminal pathways, including the trigeminal nerve and thalamic tracts. This technique accurately located pain and somatosensory pathways, aiding understanding of trigeminal system function.

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Area of Science:

  • Neuroimaging
  • Neuroanatomy
  • Medical Physics

Background:

  • The human trigeminal system is crucial for facial pain and somatosensory processing.
  • Conventional methods have limitations in characterizing trigeminal system's detailed anatomy.
  • Understanding these pathways is vital for diagnosing and treating neurological conditions.

Purpose of the Study:

  • To implement diffusion tensor imaging (DTI) and probabilistic tractography for detailed mapping of the human trigeminal system.
  • To segment and identify peripheral and central trigeminal pathways and related somatosensory tracts.
  • To compare DTI findings with existing functional and histological data.

Main Methods:

  • Diffusion tensor imaging (DTI) and probabilistic tractography were utilized.

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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia
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  • Segmentation of peripheral trigeminal circuitry, including nerve branches, ganglion, and nerve root.
  • Identification of central pathways: spinal trigeminal and trigeminal thalamic tracts, and related somatosensory systems (AL, TL, ML).

    • Main Results:

    • Successful segmentation of the trigeminal nerve branches (ophthalmic, maxillary, mandibular), ganglion, and nerve root.
    • Detailed mapping of the spinal trigeminal and trigeminal thalamic tracts.
    • Accurate identification of spinal thalamic (AL), trigeminal lemniscus (TL), and medial lemniscus (ML) pathways, correlating well with histological data.

    Conclusions:

    • DTI and probabilistic tractography are effective tools for visualizing and understanding the structural properties of the trigeminal system.
    • This imaging approach provides a valuable method for studying trigeminal system anatomy and function.
    • Further application in conjunction with functional studies can elucidate changes in trigeminal pathology.