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Updated: Jun 28, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

[Main flavonoids from Sophora flavescenes].

Wei Li¹, Hong Liang, Ting Yin

¹Department of Natural Medicines and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica

|October 30, 2008

Summary

Researchers isolated six main flavanonoids from Radix Sophorae Flavescentis, including a new compound and one previously unobtained from this source. This provides crucial reference compounds for flavanonoid analysis and bioactivity studies.

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Area of Science:

Phytochemistry
Natural Product Chemistry
Traditional Chinese Medicine

Context:

Radix Sophorae Flavescentis (Sophora flavescens roots) is a traditional Chinese medicine used for various ailments.
The primary bioactive constituents are alkaloids and flavonoids.
Flavonoids are recognized for their diverse biological activities.

Purpose:

To isolate and identify key flavanonoids from Radix Sophorae Flavescentis.
To provide reference standards for High-Performance Liquid Chromatography-Diode Array Detection (HPLC-DAD) qualitative analysis.
To support further research into the bioactivities of these flavanonoids.

Summary:

Six main flavanonoids were successfully isolated from the roots of Sophora flavescens.
These include 5-methoxy-7, 2', 4'-trihydroxy-8-[3,3-dimethylallyl]-flavanone (a new compound), isoxanthohumol, 3β,7,4'-trihydroxy-5-methoxy-8-[3,3-dimethylallyl]-flavanone (newly reported in this plant), nor-kurarinone (2S)-sophoraflavanone G, kurarinone, and kushenol I.

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Last Updated: Jun 28, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

The 13C NMR data for compounds 3 and 5 are reported for the first time, enhancing their characterization.

Impact:

The isolated compounds serve as valuable reference materials for the quality control of Radix Sophorae Flavescentis preparations.
This research facilitates accurate identification and quantification of flavanonoids in traditional Chinese medicine.
The findings contribute to a deeper understanding of the chemical composition of Sophora flavescens and its potential therapeutic applications.