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Related Concept Videos

Antibiotic Selection00:57

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Overview
Types of Selection01:46

Types of Selection

Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.Positive Frequency-Dependent SelectionIn positive...
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
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Selectome: a database of positive selection.

Estelle Proux1, Romain A Studer, Sébastien Moretti

  • 1Department of Ecology and Evolution, Biophore, Lausanne University and Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.

Nucleic Acids Research
|October 30, 2008
PubMed
Summary
This summary is machine-generated.

Selectome is a new database that identifies protein sites and phylogenetic branches affected by positive selection. This tool aids evolutionary biologists in understanding molecular evolution and adaptation.

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Area of Science:

  • Evolutionary biology
  • Molecular evolution
  • Bioinformatics

Background:

  • Genome-wide scans reveal frequent positive selection at the molecular level.
  • Identifying specific protein sites and phylogenetic branches under selection is crucial for understanding evolutionary processes.

Purpose of the Study:

  • To present Selectome, a comprehensive database detailing results of branch-site specific likelihood tests for positive selection.
  • To provide a user-friendly web interface for accessing and visualizing selection test outcomes.

Main Methods:

  • Development of a database (Selectome) storing results from branch-site specific likelihood tests for positive selection.
  • Implementation of a web interface for querying and visualizing results mapped onto phylogenetic trees and protein alignments.

Main Results:

  • Selectome provides a rigorous assessment of positive selection across protein sites and phylogenetic branches.
  • The database allows for rapid access to results via keyword, gene name, or taxonomy-based searches.
  • Test outcomes are visualized on phylogenetic trees and protein alignments for intuitive interpretation.

Conclusions:

  • Selectome offers a valuable resource for researchers investigating molecular adaptation and evolution.
  • The database facilitates the identification of key evolutionary events and functional constraints on proteins.