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Related Experiment Video

Updated: Jun 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

[Retina and glaucoma: therapeutic considerations].

F Aptel¹, P Denis

¹Service d'Ophtalmologie, Pavillon C, Hôpital Edouard-Herriot, 5, place d'Arsonval, 69437 Lyon cedex 03, France.

Journal Francais D'Ophtalmologie

|October 30, 2008

Summary

Intravitreal injections for retinal diseases can elevate intraocular pressure (IOP), potentially causing steroid glaucoma. Prostaglandin analogs may be linked to cystoid macular edema (CME) in at-risk patients.

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Published on: February 15, 2022

Area of Science:

Ophthalmology
Retinal Diseases
Glaucoma Research

Context:

Intravitreal drug delivery, including VEGF inhibitors and glucocorticoids, is increasingly used for retinal conditions.
This method offers high local drug concentrations but can lead to elevated intraocular pressure (IOP).

Purpose:

To review the interactions between retinal diseases, their treatments, and their effects on intraocular pressure (IOP).
To discuss steroid glaucoma secondary to intravitreal glucocorticoids and the potential link between prostaglandin analogs (PGAs) and cystoid macular edema (CME).

Summary:

Intravitreal glucocorticoids, like triamcinolone, can induce short-term and chronic IOP elevation, leading to steroid glaucoma.
While prostaglandin analogs (PGAs) have been associated with CME, most cases in treated eyes involved pre-existing risk factors and blood-aqueous barrier disruption.
The review suggests PGAs can be used cautiously in eyes at risk for CME.

Impact:

Highlights the risks of elevated IOP and steroid glaucoma with intravitreal glucocorticoid therapy.
Clarifies the association between PGAs and CME, emphasizing patient-specific risk factors.
Provides guidance for prudent use of PGAs in patients susceptible to CME.