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Updated: Jun 28, 2026

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease
03:25

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Published on: December 27, 2024

Chronic unexplained diarrhea: what to do when the initial workup is negative?

Nicholas J Talley1

  • 1Department of Internal Medicine, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.

Reviews in Gastroenterological Disorders
|October 30, 2008
PubMed
Summary

Diagnosing chronic diarrhea remains challenging. Evidence supporting functional diarrhea as a distinct diagnosis is unconvincing, unlike diarrhea-predominant irritable bowel syndrome.

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Last Updated: Jun 28, 2026

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease
03:25

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Published on: December 27, 2024

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Clinical Diagnosis

Background:

  • Chronic diarrhea diagnosis presents significant challenges despite advanced testing.
  • Initial assessment involves categorizing diarrhea by pathophysiology (osmotic, secretory, inflammatory, motility-related) to guide management.
  • Gastroenterologists face uncertainty regarding the extent of diagnostic workup and criteria for diagnosing functional diarrhea.

Observation:

  • The diagnostic pathway for chronic diarrhea requires careful consideration of underlying causes.
  • Distinguishing functional diarrhea from other diarrheal disorders, such as diarrhea-predominant irritable bowel syndrome, is complex.

Findings:

  • The evidence supporting functional diarrhea as a distinct diagnostic entity is notably weak.
  • Current diagnostic criteria and evidence base for functional diarrhea are unconvincing.

Implications:

  • Re-evaluation of the diagnostic criteria and evidence for functional diarrhea is warranted.
  • Further research is needed to clarify the pathophysiology and diagnostic boundaries of functional diarrhea.
  • Clinical practice may need to adapt based on the limited evidence for functional diarrhea as a standalone diagnosis.