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Published on: June 28, 2021
A case of IgG4-associated cholangitis and autoimmune pancreatitis responsive to corticosteroids
Aaron J Small1, Conor G Loftus, Thomas C Smyrk
1Internal Medicine, New York-Presbyterian Hospital/Weill Cornell Medical College, NY, USA.
Background:
A 72-year-old male presented to the emergency department with epigastric pain, anorexia and progressive jaundice of 1 week's duration. He had no prior history of gastrointestinal illness, diabetes or cancer. He did not smoke or consume alcohol. He did have a family history of colon and bone cancer.
Investigations:
Biochemical and serologic studies, CT scan, abdominal ultrasound, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, biliary cytology, pancreas needle biopsies and immunohistochemical stainings.
Diagnosis:
Autoimmune pancreatitis with IgG(4)-associated sclerosing cholangitis affecting the extrahepatic biliary ducts and mimicking primary sclerosing cholangitis and cholangiocarcinoma.
Management:
Corticosteroids and immunomodulatory therapy.
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