Related Experiment Video
Updated: Jun 28, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
[Immune tolerance therapy for inhibitors in haemophilia A]
1Institute of Experimental Haematology, and Transfusion Medicine University Clinic Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. johannes.oldenburg@ukb.uni-bonn.de
Abstract:
The development of inhibitors at start of therapy with factor VIII concentrates represent the most serious complication of haemophilia treatment. The only way to a long lasting eradication of the inhibitor is the induction of immune tolerance. A successful immune tolerance therapy (ITT) is the precondition for a regular prophylactic treatment regime and subsequently safe life perspective with a good quality of life. All ITT protocols have been developed empirically without knowing the pathophysiological mechanisms. The guidelines of the Federal Chamber of Physicians (1), the German recommendations for ITT (2) and the consensus recommendations of an international working group (3) provide an important lead for the conduction of immune tolerance therapy.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Inhibitors of Viral Protein Synthesis
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Venous Thrombosis III: Interprofessional Care
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

