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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Updated: Jun 28, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
08:13

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

[Backpain and haemophilia].

A Seuser1, B Niemann, P H Pennekamp

  • 1Chefarzt der Abteilung für Orthopädie, Kaiser-Karl-Klinik, Graurheindorfer Str. 137, 53117 Bonn, Germany. Seuser@Kaiser-Karl-Klinik.de

Hamostaseologie
|November 5, 2008
PubMed
Summary

Back pain is common in hemophilia patients, often caused by hematoma and treatable with factor VIII. Patients adapt to pain, but its impact may exceed hemophilia symptoms, necessitating focused treatment.

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Area of Science:

  • Hematology
  • Orthopedics
  • Pain Management

Context:

  • Back pain is highly prevalent in the general population.
  • Limited research exists on back pain specifically within the hemophilia community.
  • Previous studies focused on lumbar or sciatic pain from hematoma in hemophilia.

Purpose:

  • To investigate the prevalence and characteristics of back pain in patients with hemophilia.
  • To compare back pain experiences in hemophilia patients to the general population.
  • To highlight the growing importance of addressing back pain in hemophilia care.

Summary:

  • Literature search (1990-2007) found only five hemophilia back pain papers, all hematoma-related and responsive to factor VIII.
  • A survey of 49 hemophilia patients revealed 70% experienced back pain, with 40% finding it more limiting than hemophilia symptoms.
  • Reported pain levels (40-70 VAS) were significant, indicating a substantial patient burden.

Impact:

  • Back pain management will become increasingly crucial for hemophilia centers.
  • As hemophilia treatments improve, non-hemophilia-related conditions like back pain will gain prominence.
  • Understanding and treating back pain can significantly improve the quality of life for individuals with hemophilia.