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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

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Published on: January 29, 2018

Rat lumbar vertebrae bone densitometry using multidetector CT.

Yi-Xiang J Wang1, James F Griffith, Hua Zhou

  • 1Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People's Republic of China. yixiang_wang@cuhk.edu.hk

European Radiology
|October 30, 2008
PubMed
Summary
This summary is machine-generated.

Clinical multidetector computed tomography (MDCT) offers a faster and accessible method for measuring bone mineral density (BMD) in rat lumbar vertebrae. This technique shows good agreement with peripheral quantitative CT (pQCT), proving reliable for research applications.

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Area of Science:

  • Biomedical Imaging
  • Osteoporosis Research
  • Small Animal Models

Background:

  • Peripheral quantitative CT (pQCT) is standard for small animal bone mineral density (BMD) but limited by availability.
  • Clinical multidetector computed tomography (MDCT) is widely accessible and presents a potential alternative for BMD assessment.

Purpose of the Study:

  • To evaluate the feasibility of using clinical 64-slice MDCT for measuring rat lumbar vertebral BMD.
  • To compare MDCT BMD measurements with established pQCT methods and assess repeatability.

Main Methods:

  • Lumbar vertebrae from 18 female Sprague-Dawley rats were scanned using clinical MDCT (2.5-mm and 0.625-mm protocols) and pQCT (1-mm protocol).
  • Comparisons included MDCT vs. pQCT, repeatability (same-day and longitudinal), and BMD changes in ovariectomized rats.
  • Intra-class correlation coefficient (ICC) and coefficient of variation (CoV) were used for analysis; examination time was recorded.

Main Results:

  • Clinical MDCT examination time (5 min) was significantly shorter than pQCT (30 min).
  • 0.625-mm MDCT acquisitions demonstrated good agreement with pQCT (ICC = 0.85) and high same-day repeatability (CoV = 1.61%).
  • Longitudinal MDCT accurately detected a 13.7% BMD reduction in ovariectomized rats over 28 days.

Conclusions:

  • Clinical MDCT is a reliable, accurate, and faster alternative to pQCT for measuring rat lumbar vertebral BMD.
  • The 0.625-mm MDCT protocol is suitable for both cross-sectional and longitudinal BMD studies in small animal models.
  • This accessible imaging technique facilitates osteoporosis research using rodent models.