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Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis

Ihor V Yosypiv1

  • 1Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA, USA. iiosipi@tulane.edu

Pediatric Nephrology (Berlin, Germany)
|October 30, 2008
PubMed

Insights

The renin-angiotensin system (RAS) is crucial for kidney development. This review explores how RAS controls ureteric bud branching morphogenesis, essential for forming a healthy renal collecting system.

Area of Science:

  • Developmental Biology
  • Renal Physiology
  • Molecular Biology

Background:

  • The renin-angiotensin system (RAS) is vital for kidney development.
  • RAS gene mutations lead to congenital kidney and renal collecting system abnormalities.
  • Mechanisms of RAS control over renal development are not fully understood.

Purpose of the Study:

  • To review the role of the RAS in ureteric bud (UB) morphogenesis.
  • To explore mechanisms by which RAS regulates UB branching.
  • To provide a framework for understanding RAS in renal development.

Main Methods:

  • Literature review focusing on RAS and kidney development.
  • Analysis of genetic and molecular pathways involved in UB morphogenesis.
  • Integration of findings on receptor tyrosine kinase and AT(1) receptor signaling.

Main Results:

  • The RAS plays a critical role in regulating ureteric bud branching morphogenesis.
  • Aberrations in RAS signaling pathways result in abnormal kidney development.
  • Cooperation between angiotensin II AT(1) receptor and receptor tyrosine kinase signaling is essential.

Conclusions:

  • The RAS is a key regulator of renal collecting system development via UB branching.
  • Understanding RAS mechanisms offers insights into congenital kidney diseases.
  • Targeting RAS pathways may hold potential for therapeutic interventions.

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