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Updated: Jun 28, 2026
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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
Diffuse malignant pleural mesothelioma: a multi-institutional clinicopathological study
Akira Iyoda1, Toshikazu Yusa, Chikabumi Kadoyama
1Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Surgery Today
|October 30, 2008
Summary
Malignant pleural mesothelioma (MPM) diagnosis and treatment in Japan are challenging due to rarity. Early diagnosis and radical surgery for resectable MPM significantly improve patient survival rates.
Area of Science:
- Oncology
- Thoracic Surgery
- Diagnostic Imaging
Background:
- Malignant pleural mesothelioma (MPM) is a rare cancer.
- Its rarity in Japan complicates single-institution clinicopathological studies.
- Multi-institutional collaboration is essential for understanding MPM.
Purpose of the Study:
- To evaluate the current diagnostic and treatment status of MPM in Japan.
- To assess prognostic factors influencing survival in MPM patients.
Main Methods:
- A multi-institutional retrospective study.
- Analysis of medical records from 65 MPM patients across 13 Japanese institutions.
- Statistical analysis including multivariate analysis for prognostic factors.
Main Results:
- Diagnosis took a median of 2 months from initial visit for 56 symptomatic patients.
- Survival rates were significantly higher for surgically treated patients (67.9% at 1 year) compared to unresectable cases (40.5% at 1 year).
- Histological type, clinical stage, sex, and shortness of breath were significant prognostic factors.
Conclusions:
- Early diagnosis of MPM remains difficult.
- Improved diagnostic modalities are crucial for better patient outcomes.
- Radical surgery offers improved survival for resectable MPM.
